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By now, most of us have smart home safety integrations in place. Smart doorbells, security cameras, floodlights, and smart locks help us stay safe. Many of these devices will send you notifications when something unexpected happens, whether a stranger is at the front door, a loud noise has been detected, or a family of raccoons has taken an interest in your garbage cans.
A different sequencing method that chemically cleaved DNA at specific bases, developed by Allan Maxam and Walter Gilbert, was the dominant technology into the 1980s. Radiolabeled DNA samples were incubated in four separate reactions, each of which contained a chemical that cleaved after a different nucleotide — either A/G, G, C, or C/T. By adding the right amount of each chemical, it was possible to produce different fragments chopped off at each individual base. The sequence could then be read using gel electrophoresis and autoradiography. Maxam–Gilbert sequencing was easier than the plus and minus method to run and interpret, but was eventually surpassed by Sanger’s chain termination method, which molecular biologists found both technically preferable and more “elegant” since it mirrored the natural copying of DNA.